impaired cognitive performance ( p = 0.02 and p = 0.04, respectively), Improvement showed strong correlation with improvements in Marsh scores and tissue transglutaminase antibody levels (r = 0.377–0.735 all p< 0.05).Ĭognition was impaired in people with untreated CD.Īdults with symptoms and signs compatible with CD MARSH improved significantly ( p = 0.001) GFD less than 4 weeks prior to the enrollment “Equivalent score” lower in CD than controls for:īarthel Index of functional performance was similar in the 2 groups.ĬD diagnosed patients (MARSH III or MARSH I and II + antibodies positivity) Mini Mental Test Examination ( p = 0.02), “Raw score” significantly lower in CD than controls for: (MARSH III in 16 patients, MARSH I-II in 2 patients) Patients aged ≥65 at the time of CD diagnosisĪll tested t-Tg or i-GA antibodies and villous atrophy Nevertheless, research on this topic is progressively increasing and future studies should address specific key points.Ĭharacteristics of the reviewed studies. We tried to establish the specific areas involved, in order to have a comprehensive view of this condition and trying to determine a correct way of assessing CD cognitive impairment and its correlations with psychological distress and personal coping skills to a chronic condition. This review demonstrated the lack of research on CD-related cognitive impairment key features and tries to focus on both cognitive and psychological manifestations as well as their two-way interaction. Based on the exclusion/inclusion criteria, a total of seven articles were included in the scoping review process.
We conducted a descriptive analysis of the characteristics of the included literature. We performed a systematic search of MEDLINE, PubMed, SCOPUS, Web of Science and Cochrane library in November 2022. The study aimed to identify emerging and urgent research domains in order to establish a CD-specific patient-tailored protocol that includes both psychological and neuropsychological evaluations. Prevalent neurologic manifestations are ataxia, epilepsy, cerebral calcification, cerebral white matter lesions, peripheral neuropathy and myopathy, but also cognitive impairment. Celiac disease is often associated with a wide range of disorders, caused by immune responses and by malabsorption with subsequent nutritional deficiencies. Celiac disease (CD), also known as gluten-sensitive enteropathy, is an inflammatory autoimmune reaction triggered by ingestion of gluten in genetically predisposed subjects.
0 kommentar(er)
